Contraindicated (1)pentobarbital will reduce the level or effect of roflumilast by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will minimize the extent or impact of tofacitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Lack of, or lessened reaction to tofacitinib may take place when coadm